3-HO-PCP

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• 3-Hydroxyphencyclidine (commonly known as 3-HO-PCP) is a novel dissociative substance of the arylcyclohexylamine class that produces potent dissociative, hallucinogenic, and euphoric effects when administered.
• In addition to its primary activity as an NMDA receptor antagonist, it has been found to have an appreciable affinity for the μ-opioid receptor.
• It was first synthesized in 1978 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives.
• It was further explored alongside PCP in the 1980s, where it was discovered to possess μ-opioid agonist activity in animal models.

Chemistry & Background Information

• The structure of 3-Hydroxyphencyclidine consists of cyclohexane. It’s a six-membered saturated ring. It consists of a piperidine ring and an aromatic phenyl ring. It was further explored together with phencyclidine in the 1980s. Researchers discovered that it possesses μ-opioid agonists.
• Like other substances in the arylcyclohexylamine class, particularly methoxetamine, phencyclidine, and 3-MeO-PCE, 3-HO-PCP is referred to as “dissociative anesthesia”, albeit the extent to which this occurs has been reported to be highly dose-dependent and variable in its research outcomes.

Chemical Formula:

• Product Name: 3-HO-PCP
• Other Name(s): 3-Hydroxyphencyclidine; PCP-3-OH
• IUPAC Name: 1-[1-(3-hydroxyphenyl)cyclohexyl]-piperidine hydrochloride
• CAS: 79787-43-2
• Molar Mass: 295.9 g/mol
• Purity: 99,8% and above